Bioinformatics Study of hsa-miR-21-5p and hsa-miR-22-3p Role in Cellular Signaling Pathways Associated with Liver Cancer

Negar Amir Yoosefi¹ Samira Mahmoudi² Negar Balmeh³ Fereshteh Mirzaei Poor⁴ Niloofar Mohammadi⁵

Abstract :
Background: Cancer is considered the disease of the century and the second leading cause of death in humans after cardiovascular disease. Cancer cells disregard cell division by disrupting the order of the body s cells. One of the world s deadliest cancers is liver cancer because the liver is one of the body s vital organs. It accounts for nearly 6 percent of all cancers in the world. The aim of this study is to propose a solution to treat and inhibit the progression of liver cancer. Methods: In this study, important miRNAs in liver cancer, from different databases such as miRCancer ، miRBase، DIANA ،GEPIA2، GeneMANIA, miRway and R software to obtain important miRNAs in liver cancer, to find their target gene and finally to investigate the role of important genes were used in cellular signaling pathways associated with liver cancer. Result: Based on the study, it was found that hsa-miR-21-5p had the highest increase in expression and hsa-miR-22-3p had the highest decrease in expression among the important miRNAs in liver cancer. Considering the number of repetitions between different cell pathways, THBS1,CDK6, EGFR,PTK2,PIK3R1,VEGFA,ITGB8,BCL2,MYC,PDGFD,STAT3,FGF18,SKP2 genes as the most important targets for hsa-miR-21-5p genes, and NRAS,MAX,AKT3,RELA,IGF1R, MLST8 ,LAMC1,CSF1R,CDK6 genes for hsa-miR-22-3p were selected in cell signaling pathways associated with liver cancer. It was indicated that hsa-miR-22-5p and hsa-miR-22-3p can have an effect on genes such as ITGB8, SKP2, BCL2, PDGFD, CDK6, FGF18, MYC, VEGFA, PTK2, EGFR, THBS, PIK3R, NRAS, RELA, IGF1R, CSF1R, and LAMC1. Conclusion: The genes are affected by hsa-miR-22-5p and hsa-miR-22-3p play an important role in the proliferation of liver cancer cells. So these two miRNAs can be used to control and prevent cancer from progressing by preventing proliferation, growth, metastasis, and regression.

Keywords : liver cancer bioinformatics hsa mir 22 5p hsa mir 22 3p

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زبان مقاله : انگلیسی
محور مقاله : علوم
محل انتشار : دومین کنگره بین المللی علوم و مهندسی - پاریس
آدرس وب سایت کنفرانس : parisconf.com
کد IOI مقاله : XCAZ-EHAAE
لینک مستقیم مقاله : https://isnac.ir/XCAZ-EHAAE
نمایش چکیده فارسی : https://isnac.ir/SA/XCAZ-EHAAE

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1. Bioinformatics Study of hsa-miR-21-5p and hsa-miR-22-3p Role in Cellular Signaling Pathways Associated with Liver Cancer

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